Cat. No.: IBDA-433219
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Online InquiryTarget Information
| Target Name | IKB Alpha |
| Uniprot ID | P25963 |
| Cellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. |
| Immunogen | Recombinant fragment corresponding to Human IKB alpha (internal sequence). |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
Product Details
| Description | Rabbit polyclonal antibody to IKB alpha. |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Immunogen affinity purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Human |
| Immunogen | Recombinant fragment corresponding to Human IKB alpha (internal sequence). |
| Positive Control | 293T, A431, H1299, HeLa, HepG2, MOLT4 and Raji whole cell lysates. HeLa cells |
| Application | ICC/IF, IHC-P, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Upon delivery aliquot. Store at -20 °C or -80 °C |
| Storage Buffer | pH: 7 Preservative: 0.025% Proclin 300 Constituent: 78% PBS, 1% BSA, 20% Glycerol |
| Handling | Avoid freeze-thaw cycles. |