IKB Beta Monoclonal Antibody

Target Information

Target Name	IKB Beta
Uniprot ID	Q15653
Cellular Localization	Cytoplasm. Nucleus.
Immunogen	Synthetic peptide.
Function	Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Product Details

Description	Rabbit monoclonal antibody to IKB beta.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide.
Positive Control	WB: Jurkat, HeLa, THP-1, and MCF7 cell lysates. IP: HeLa cells. IHC-P: Human kidney tissue. ICC/IF: Jurkat cells. Flow Cyt (Intra): Jurkat cells.
Application	Flo, ICC/IF, IHC-P, IP, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 59% PBS, 40% Glycerol, 0.05% BSA
Handling	Avoid freeze-thaw cycles.