Cat. No.: IBDA-431492
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Online InquiryTarget Information
| Target Name | IKB zeta |
| Uniprot ID | Q9BYH8 |
| Cellular Localization | Nucleus. Aggregated in dot-like structures. Colocalizes with NCOR2. |
| Function | Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis. |
Product Details
| Description | Rabbit polyclonal antibody to IKB zeta. |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Immunogen affinity purified |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Positive Control | ICC/IF: RT4 cells. |
| Application | ICC/IF |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.20 Preservative: 0.02% Sodium Azide Constituent: 40% Glycerol, PBS |
| Handling | Avoid freeze-thaw cycles. |