IKB zeta Polyclonal Antibody

Target Information

Target Name	IKB zeta
Uniprot ID	Q9BYH8
Cellular Localization	Nucleus. Aggregated in dot-like structures. Colocalizes with NCOR2.
Immunogen	Recombinant fragment, corresponding to a region within amino acids 303-609 of Human IKB zeta .
Function	Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis.

Product Details

Description	Rabbit polyclonal antibody to IKB zeta.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant fragment, corresponding to a region within amino acids 303-609 of Human IKB zeta .
Positive Control	HeLa nuclear lysate.
Application	WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	pH: 7 Preservative: 0.01% Thimerosal (Merthiolate) Constituent: 1.21% Tris, 0.75% Glycine, 20% Glycerol
Handling	Avoid freeze-thaw cycles.