Cat. No.: IBDA-435264
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Online InquiryTarget Information
| Target Name | IKK Alpha |
| Uniprot ID | O15111 |
| Cellular Localization | Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus. |
| Immunogen | Synthetic peptide. |
| Function | Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines. |
Product Details
| Description | Rabbit monoclonal antibody to IKK alpha - BSA and Azide Free. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Positive Control | WB: Jurkat, HeLa, HepG2 and Daudi cell lysates. ICC/IF: HeLa cells. IHC: Human breast tissue IP: Jurkat cell lysate. Flow Cyt: HeLa cells. |
| Application | Flo, ICC/IF, IHC-P, IP, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at 4 °C |
| Storage Buffer | Constituent: PBS |
| Handling | Do not freeze. |