IKK Alpha Monoclonal Antibody

Target Information

Target Name	IKK Alpha
Uniprot ID	O15111
Cellular Localization	Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus.
Function	Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

Product Details

Description	Mouse monoclonal antibody to IKK alpha.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein G purified
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Mouse, Human
Positive Control	WB: HeLa, MCF7, U-87 MG, PC-3 and HEK-293 cell lysates. mouse small intestine lysate. Flow Cyt: Jurkat, HEK-293 and HeLa cells.
Application	Flo, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	Preservative: 0.05% Sodium Azide Constituent: PBS, 0.05% BSA
Handling	Avoid freeze-thaw cycles.