IKK Alpha (phospho S176 + S180) Polyclonal Antibody

Target Information

Target Name	IKK Alpha (phospho S176 + S180)
Uniprot ID	O15111
Cellular Localization	Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus.
Immunogen	Synthetic peptide corresponding to IKK alpha (phospho S176 + S180).
Function	Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

Product Details

Description	Rabbit polyclonal antibody to IKK alpha (phospho S176 + S180).
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide corresponding to IKK alpha (phospho S176 + S180).
Application	ICC/IF, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	pH: 7.30 Preservative: 0.05% Sodium Azide Constituent: PBS, 0.1% BSA PBS is Ca2+ and Mg2+ free
Handling	Avoid freeze-thaw cycles.