IKK Alpha Polyclonal Antibody

Target Information

Target Name	IKK Alpha
Uniprot ID	O15111
Cellular Localization	Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus.
Immunogen	Synthetic peptide within Human IKK alpha aa 550-600.
Function	Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

Product Details

Description	Rabbit polyclonal antibody to IKK alpha.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide within Human IKK alpha aa 550-600.
Positive Control	IP: Jurkat whole cell lysate.
Application	IP

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7 Preservative: 0.09% Sodium Azide Constituent: Tris Citrate/Phosphate
Handling	Avoid freeze-thaw cycles.