IKK Gamma/NEMO Monoclonal Antibody

Target Information

Target Name	IKK Gamma/NEMO
Uniprot ID	Q9Y6K9
Cellular Localization	Cytoplasm. Nucleus. Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.
Immunogen	Recombinant full length protein.
Function	Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity (By similarity). Essential for viral activation of IRF3.

Product Details

Description	Rabbit monoclonal antibody to IKK gamma/NEMO.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Rat, Human
Immunogen	Recombinant full length protein.
Positive Control	WB: Human fetal brain and kidney tissue lysates. Human colon cancer tissue lysate. HeLa, K562, Jurkat, HEK293T C6, RAW 264.7, PC-12 and NIH/3T3 cell lysates. Mouse brain, heart, kidney and spleen tissue lysates. Rat brain, heart, kidney and spleen tissue lysates. IHC-P: Human colonic adenocarcinoma, rat colon. ICC/IF: HeLa, NIH/3T3
Application	ICC/IF, IHC-P, IP, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	Preservative: 0.01% Sodium Azide Constituent: 59% PBS, 40% Glycerol, 0.05% BSA
Handling	Avoid freeze-thaw cycles.