IL-12B Monoclonal Antibody

Target Information

Target Name	IL-12B
Uniprot ID	P29460
Cellular Localization	Secreted.
Immunogen	Synthetic peptide.
Function	Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Product Details

Description	Rabbit monoclonal antibody to IL-12B.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide.
Positive Control	WB: Human IL-12B recombinant protein. ICC/IF: MOLT-4 cells Flow Cyt (Intra): Jurkat cells.
Application	Flo, ICC/IF, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: PBS, 40% Glycerol, 0.05% BSA
Handling	Avoid freeze-thaw cycles.