IL37 Monoclonal Antibody - BSA and Azide Free

Target Information

Target Name	IL37
Uniprot ID	Q9NZH6
Cellular Localization	Cytoplasm > cytosol. Nucleus. Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
Immunogen	Recombinant fragment.
Function	Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.

Product Details

Description	Rabbit monoclonal antibody to IL37 - BSA and Azide Free.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant fragment.
Positive Control	WB: Untreated THP-1 (human monocytic leukemia monocyte) whole cell lysate. THP-1 treated with 100nM PMA for 16 hours. And then with 100 ng/ml LPS for 4 hours, and then 1 µg/ml Brefeldin A was added for 3 hours, whole cell lysate. Human testis tissue lysate. Human IL-37 recombinant protein. IHC-P: Human testis and skin. ICC/IF: THP-1 cells. IP: THP-1 treated with 100nM PMA for 16 hours. And then with 100ng/ml LPS for 4 hours, and then 1µg/ml Brefeldin A was added for 3 hours whole cell lysate.
Application	ICC/IF, IHC-P, IP, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at 4 °C
Storage Buffer	Constituent: 100% PBS