Ingenol 3,20-dibenzoate

Cat. No.: IBDI-431095

Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells.

Product Details

Target	PKC | Apoptosis
Molecular Weight	556.65
Appearance	Solid
SMILES	O[[email protected]]([[email protected]]1OC(C2=CC=CC=C2)=O)([[email protected]@H](C(COC(C3=CC=CC=C3)=O)=C4)O)[[email protected]]([[email protected]@H]5C)(C=C1C)C([[email protected]]4[[email protected]@](C(C)6C)([H])[[email protected]@]6([H])C5)=O
Structure Classification	Terpenoids>Diterpenoids
Purity	99.31%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.