Inobrodib

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Cat. No.: IBDI-437287

Inobrodib (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. Inobrodib binds to p300 and CBP with Kd values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a Kd of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	Epigenetic Reader Domain
Molecular Weight	534.60
Appearance	Solid
Synonyms	CCS1477
SMILES	O=C1N(C2=CC=C(F)C(F)=C2)[[email protected]](C3=NC4=CC(C5=C(C)ON=C5C)=CC=C4N3[[email protected]]6CC[[email protected]](OC)CC6)CCC1
Purity	99.42%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.