Cat. No.: IBDA-434019
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Online InquiryTarget Information
| Target Name | Integrin Alpha 4/CD49D |
| Uniprot ID | P13612 |
| Cellular Localization | Membrane. |
| Immunogen | Recombinant fragment. |
| Function | Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. |
Product Details
| Description | Rabbit monoclonal antibody to Integrin alpha 4/CD49D - BSA and Azide Free. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Recombinant fragment. |
| Positive Control | Flow Cyt: PBMC and Jurkat, HAP1 cells. Flow Cyt (Intra): HEK-293T transfected with a human Integrin alpha 4 expression vector containing a myc-his tag |
| Application | Flo, Flo |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at 4 °C |
| Storage Buffer | pH: 7.2 Constituent: 100% PBS |