Integrin Alpha 4/CD49D Monoclonal Antibody

Target Information

Target Name	Integrin Alpha 4/CD49D
Uniprot ID	P13612
Cellular Localization	Membrane.
Immunogen	Synthetic peptide within Human Integrin alpha 4/CD49D aa 1000-1100 (C terminal).
Function	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

Product Details

Description	Rabbit monoclonal antibody to Integrin alpha 4/CD49D.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide within Human Integrin alpha 4/CD49D aa 1000-1100 (C terminal).
Positive Control	Jurkat whole cell lysate
Application	WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue Culture Supernatant
Handling	Avoid freeze-thaw cycles.