Integrin Alpha 4/CD49D Monoclonal Antibody

Target Information

Target Name	Integrin Alpha 4/CD49D
Uniprot ID	P13612
Cellular Localization	Membrane.
Immunogen	Tissue, cells or virus corresponding to Integrin alpha 4/CD49D.
Function	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

Product Details

Description	Mouse monoclonal antibody to Integrin alpha 4/CD49D.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Tissue, cells or virus corresponding to Integrin alpha 4/CD49D.
Positive Control	Flow Cyt: Human whole peripheral blood cells. IHC-Fr: Human tonsil tissue. ICC/IF: Wild-type HAP-1 cells.
Application	Flo, ICC/IF

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	Preservative: 0.1% Sodium Azide Constituent: PBS
Handling	Avoid freeze-thaw cycles.