Integrin Beta 3 Monoclonal Antibody

Target Information

Target Name	Integrin Beta 3
Uniprot ID	P05106
Cellular Localization	Membrane.
Immunogen	Tissue, cells or virus corresponding to Human Integrin beta 3.
Function	Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Product Details

Description	Mouse monoclonal antibody to Integrin beta 3.
Host Species	Mouse
Clonality	Monoclonal
Purity	Tissue culture supernatant
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Tissue, cells or virus corresponding to Human Integrin beta 3.
Positive Control	Tonsil.
Application	IHC-P

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.3 Preservative: 0.05% Sodium Azide Constituent: Tissue Culture Supernatant, 1% BSA
Handling	Avoid freeze-thaw cycles.