IRAK-1 Monoclonal Antibody

Target Information

Target Name	IRAK-1
Immunogen	Recombinant fragment.
Function	Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.

Product Details

Description	Rabbit monoclonal antibody to IRAK-1.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant fragment.
Positive Control	WB: Whole cell lysates: Wild-type HAP1 (human chronic myelogenous leukemia near-haploid cell line), HeLa (human cervical adenocarcinoma epithelial cell). human: tonsil tissue lysate, hypothalamus tissue lysate. IHC-P: Human: colon carcinoma tissue, lung cancer and adjacent tissue, wild-type HAP1 (Human chronic myelogenous leukemia near-haploid cell) cell pellet.
Application	IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.2 Preservative: 0.01% Sodium Azide Constituent: 59% PBS, 40% Glycerol, 0.05% BSA
Handling	Avoid freeze-thaw cycles.