Cat. No.: IBDA-435473
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Online InquiryTarget Information
| Target Name | IRAK-1 (phospho T387) |
| Immunogen | Synthetic peptide corresponding to Human IRAK-1 (phospho T387). |
| Function | Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1. |
Product Details
| Description | Rabbit polyclonal antibody to IRAK-1 (phospho T387). |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Immunogen affinity purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse |
| Immunogen | Synthetic peptide corresponding to Human IRAK-1 (phospho T387). |
| Positive Control | NIH3T3 cells. |
| Application | ICC/IF |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: 0.88% Sodium Chloride, 50% Glycerol, 49% PBS |
| Handling | Avoid freeze-thaw cycles. |