IRAK-1 Polyclonal Antibody

Target Information

Target Name	IRAK-1
Immunogen	Synthetic peptide corresponding to Human IRAK-1 aa 700-712 (C terminal).
Function	Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.

Product Details

Description	Rabbit polyclonal antibody to IRAK-1.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Rat, Human
Immunogen	Synthetic peptide corresponding to Human IRAK-1 aa 700-712 (C terminal).
Positive Control	WB: L1210 and YB2/0 cell lysates (Human, Mouse & Rat). ICC: HeLa and murine RAW 264.7 cells (Human).
Application	ICC, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.2 Preservative: 0.02% Sodium Azide Constituent: PBS
Handling	Avoid freeze-thaw cycles.