IRGM Polyclonal Antibody

Target Information

Target Name	IRGM
Uniprot ID	A1A4Y4
Cellular Localization	Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle > phagosome membrane. Cytoplasmic vesicle > autophagosome membrane. Cell projection > phagocytic cup. Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi.
Immunogen	Synthetic peptide corresponding to 14 amino acids from near the centre of Human IRGM.
Function	Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility.

Product Details

Description	Rabbit polyclonal antibody to IRGM.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide corresponding to 14 amino acids from near the centre of Human IRGM.
Positive Control	Human Colon and Brain tissue.
Application	IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20 °C or -80 °C. Store undiluted
Storage Buffer	pH: 7.4 Preservative: 0.02% Sodium Azide Constituent: 99% PBS
Handling	Avoid freeze-thaw cycles.