Cat. No.: IBDA-435352
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Online InquiryTarget Information
| Target Name | IRGM |
| Uniprot ID | A1A4Y4 |
| Cellular Localization | Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle > phagosome membrane. Cytoplasmic vesicle > autophagosome membrane. Cell projection > phagocytic cup. Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi. |
| Immunogen | A 17 amino acid peptide near the amino terminus of human IRGM. |
| Function | Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility. |
Product Details
| Description | Rabbit polyclonal antibody to IRGM. |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Immunogen affinity purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | A 17 amino acid peptide near the amino terminus of human IRGM. |
| Application | ICC/IF, IHC-P, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.2 Preservative: 0.02% Sodium Azide Constituent: PBS |
| Handling | Avoid freeze-thaw cycles. |