Isofistularin-3

Cat. No.: IBDI-433731

Isofistularin-3 is a direct, DNA-competitive DNMT1 inhibitor, with an IC50 of 13.5 μM. Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytotoxin.

Product Details

Target	DNA MethyltransfeRase | ADC Cytotoxin | Autophagy | Apoptosis
Molecular Weight	1114.01
SMILES	COC1=C(Br)[[email protected]](O)[[email protected]@]2(ON=C(C(NC[[email protected]](O)COC3=C(Br)C=C([[email protected]](O)CNC(C4=NO[[email protected]]5(C4)C=C(Br)C(OC)=C(Br)[[email protected]]5O)=O)C=C3Br)=O)C2)C=C1Br

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.