JNJ-1013

Cat. No.: IBDI-433718

JNJ-1013 is a potent and selective IRAK1 degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces Apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705).

Product Details

Target	Apoptosis | IRAK
Molecular Weight	878.05
Appearance	Solid
SMILES	COC(C=C1N(CC2)CCC2OCC(N[[email protected]@H](C(C)(C)C)C(N3[[email protected]@H](C[[email protected]](C3)O)C(N[[email protected]](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)=O)=O)=C(C=C1)NC(C6=CC=CC(C7=NNC=C7)=N6)=O
Purity	99.23%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.