JNK1 + JNK2 Polyclonal Antibody

Target Information

Target Name	JNK1 + JNK2
Immunogen	Synthetic peptide corresponding to Human JNK1 + JNK2 (internal sequence).
Function	Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Product Details

Description	Rabbit polyclonal antibody to JNK1 + JNK2.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Rat, Human
Immunogen	Synthetic peptide corresponding to Human JNK1 + JNK2 (internal sequence).
Application	IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C
Storage Buffer	Preservatives: 0.025% Thimerosal (Merthiolate), 0.025% Sodium Azide Constituent: 2.5% BSA, 0.45% Sodium Chloride, 0.1% Dibasic Monohydrogen Sodium Phosphate
Handling	Avoid freeze-thaw cycles.