JNK1 Monoclonal Antibody

Target Information

Target Name	JNK1
Immunogen	Purified recombinant fragment of Human JNK1 expressed in E. coli.
Function	Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Product Details

Description	Mouse monoclonal antibody to JNK1.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein G purified
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Mouse, Rat, Human, Recombinant fragment
Immunogen	Purified recombinant fragment of Human JNK1 expressed in E. coli.
Positive Control	A431, K562, NIH3T3, PC-12, and MCF-7 cell lysates. HeLa cells
Application	Flo, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	Preservative: 0.05% Sodium Azide Constituent: 99% PBS
Handling	Avoid freeze-thaw cycles.