Cat. No.: IBDA-435610
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Online InquiryTarget Information
| Target Name | JNK1 (phospho T183 + Y185) |
| Immunogen | Synthetic peptide within Human JNK1 (phospho T183 + Y185). |
| Function | Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. |
Product Details
| Description | Rabbit monoclonal antibody to JNK1 (phospho T183 + Y185). |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A/G purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Human |
| Immunogen | Synthetic peptide within Human JNK1 (phospho T183 + Y185). |
| Positive Control | Flow Cyt: HEK-293T cells 9treated with UV + TPA). |
| Application | Flo |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | Preservative: 0.02% Sodium Azide Constituent: 49.88% PBS, 50% Glycerol, 0.1% BSA |
| Handling | Avoid freeze-thaw cycles. |