Cat. No.: IBDA-435592
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Online InquiryTarget Information
| Target Name | JNK2 |
| Immunogen | Synthetic peptide. |
| Function | Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it. |
Product Details
| Description | Rabbit monoclonal antibody to JNK2 - BSA and Azide Free. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Positive Control | WB: HEK293T, MCF7, HAP1 and HeLa cell lysates. IP: HeLa cell lysate. Flow Cyt (Intra): HeLa cells. IHC-P: Human breast carcinoma tissue. |
| Application | ELISA, Flo, IHC-P, IP, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at 4 °C |
| Storage Buffer | pH: 7.20 Constituent: PBS |
| Handling | Do not freeze. |