JNK2 Monoclonal Antibody

Target Information

Target Name	JNK2
Immunogen	Synthetic peptide.
Function	Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Product Details

Description	Rabbit monoclonal antibody to JNK2.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human, Recombinant fragment
Immunogen	Synthetic peptide.
Positive Control	WB: HEK293T, MCF7, HAP1 and HeLa cell lysates. IHC-P: Human breast carcinoma tissue. IP: HeLa cell lysate. Flow Cyt (Intra): HeLa cells.
Application	ELISA, Flo, IHC-P, IP, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 59% PBS, 40% Glycerol, 0.5% BSA
Handling	Avoid freeze-thaw cycles.