JNK2 Polyclonal Antibody

Target Information

Target Name	JNK2
Immunogen	Recombinant full length protein corresponding to Human JNK2 aa 1-424.
Function	Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Product Details

Description	Rabbit polyclonal antibody to JNK2.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Protein G purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant full length protein corresponding to Human JNK2 aa 1-424.
Positive Control	ICC/IF: HeLa cells. IP: HeLa whole cell lysate.
Application	ICC/IF, IP

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.40 Constituent: 50% Glycerol, PBS, 0.03% Proclin 300
Handling	Avoid freeze-thaw cycles.