JNK2 Polyclonal Antibody

Target Information

Target Name	JNK2
Immunogen	Synthetic peptide: ELVKGCVIFQGTDH , corresponding to internal sequence amino acids 217-230 of Human JNK2.
Function	Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Product Details

Description	Goat polyclonal antibody to JNK2.
Host Species	Goat
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide: ELVKGCVIFQGTDH , corresponding to internal sequence amino acids 217-230 of Human JNK2.
Positive Control	HeLa cell line lysate
Application	WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C
Storage Buffer	pH: 7.30 Preservative: 0.02% Sodium Azide Constituent: 99% Tris Buffered Saline, 0.5% BSA
Handling	Avoid freeze-thaw cycles.