JQ-1 (carboxylic acid)

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Cat. No.: IBDI-433426

JQ-1 carboxylic acid, a type of (+)-JQ-1 derivative, is a potent BET bromodomain inhibitor for downregulating PD-L1 expression on the surface of tumor cells. JQ-1 carboxylic acid can be used as a precursor to synthesize PROTACs, which targets BET bromodomains.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	Epigenetic Reader Domain \| PD-1/PD-L1
Molecular Weight	400.88
Appearance	Solid
SMILES	ClC1=CC=C(C(C2=C(N3C4=NN=C3C)SC(C)=C2C)=N[[email protected]]4CC(O)=O)C=C1
Purity	99.82%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.