KRAS G12C inhibitor 44

Cat. No.: IBDI-435026

KRAS G12C inhibitor 44 (compound 54) is a potent and orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 shows anti-proliferation activities with IC50s of 0.016, 0.028 µM in MIA PaCA-2, H358 cells, respectively. KRAS G12C inhibitor 44 shows antitumor effects in vivo.

Product Details

Target	Ras
Molecular Weight	579.11
SMILES	O=C(C(F)=C)N(CC1)[[email protected]@H](CC#N)CN1C2=NC(OC[[email protected]]3N(C)CCC3)=NC4=C2CC[[email protected]]5(C4)CCC6=C(Cl)C=CC=C65

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.