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KRAS G12C inhibitor 47

Cat. No.: IBDI-437354

KRAS G12C inhibitor 47 (compound 8-1-1) is a potent KRAS G12C inhibitor with an IC50 of 0.172 µM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC50s of 0.046, 69.8 µM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers.

Size (Solid):

Product Details

Target Ras
Molecular Weight 547.02
SMILES O=C1N=C(N2CCN(CC2)C(C=C)=O)C3=C(N1C4=C(C(C)C)C=CC=C4)C=C(C5=C(O)C=CC=C5F)C(Cl)=C3

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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