Lenalidomide-C4-NH2 hydrochloride

Cat. No.: IBDI-435034

Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively.

Product Details

Target	E3 Ligase Ligand-Linker Conjugates
Molecular Weight	351.83
Appearance	Solid
Synonyms	Cereblon ligand 1 hydrochloride, E3 ligase Ligand-Linker Conjugates 32 hydrochloride
SMILES	O=C(C(N(CC1=C2C=CC=C1CCCCN)C2=O)CC3)NC3=O.Cl
Purity	98.85%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.