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* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Leptomycin B

Cat. No.: IBDI-436572

Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.

Size (Solid):

Product Details

Target CRM1 | Fungal | Antibiotic
Molecular Weight 540.73
Appearance <41°C Solid, >44°C Liquid
Synonyms CI 940, LMB
SMILES O=C(O)/C=C(C)/C[[email protected]](C)[[email protected]@H](O)[[email protected]](C)C([[email protected]](C)/C=C(C)/C=C/C[[email protected]@H](C)/C=C(CC)\C=C\[[email protected]]1[[email protected]@H](C)C=CC(O1)=O)=O
Purity 99.54%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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