Lometrexol hydrate

Cat. No.: IBDI-436685

Lometrexol (DDATHF) hydrate, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.

Product Details

Target	Antifolate | Apoptosis | Caspase | Bcl-2 Family
Molecular Weight	461.47
Appearance	Solid
Synonyms	DDATHF hydrate
SMILES	O=C(O)CC[[email protected]@H](C(O)=O)NC(C1=CC=C(CC[[email protected]@H](CN2)CC3=C2N=C(N)NC3=O)C=C1)=O.O
Purity	≥99.0%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.