LXR antagonist 2

Cat. No.: IBDI-432533

LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, with IC50 values of 0.36 and 2.25 μM for LXRβ and LXRα, respectively. LXR antagonist 2 is a lipogenesis inhibitor through down-regulating LXR target genes SREBP-1c, ACC, FAS and SCD-1. LXR antagonist 2 shows lipid-lowering effects in mice with Triton WR-1339-induced hyperlipidemia.

Product Details

Target	LXR
Molecular Weight	588.76
SMILES	CC([[email protected]]1N(CC[[email protected]]12C(N(C3=C2C=CC=C3)C4=CC=CC(C5=CC=C(C(S(C)(=O)=O)=C5)CO)=C4)=O)C(CC(C)(C)C)=O)C

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.