M6PR (cation independent) Monoclonal Antibody

Target Information

Target Name	M6PR (cation independent)
Uniprot ID	P11717
Cellular Localization	Lysosome membrane. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
Immunogen	Synthetic peptide within Human M6PR (cation independent) aa 2450 to the C-terminus (C terminal).
Function	Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Product Details

Description	Rabbit monoclonal antibody to M6PR (cation independent).
Host Species	Rabbit
Clonality	Monoclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Rat, Human
Immunogen	Synthetic peptide within Human M6PR (cation independent) aa 2450 to the C-terminus (C terminal).
Positive Control	Jurkat, 293T, C6, PC-12, NIH/3T3 and Caco-2 cell lysates. Human papillary carcinoma, thyroid and tonsil tissue. Mouse heart, kidney, colon and spleen tissue. Rat colon tissue . ICC/IF: HAP1 WT and HAP1-IGF2R knockout cells
Application	Flo, ICC/IF, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 40% Glycerol, 0.05% BSA, 59% PBS
Handling	Avoid freeze-thaw cycles.