M6PR (cation independent) Monoclonal Antibody

Target Information

Target Name	M6PR (cation independent)
Uniprot ID	P11717
Cellular Localization	Lysosome membrane. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
Immunogen	Full length native protein (purified) corresponding to Cow M6PR (cation independent).
Function	Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Product Details

Description	Mouse monoclonal antibody to M6PR (cation independent).
Host Species	Mouse
Clonality	Monoclonal
Purity	IgG fraction
Isotype	IgG
Conjugation	Alexa Fluor® 488
Reactivity	Human
Immunogen	Full length native protein (purified) corresponding to Cow M6PR (cation independent).
Positive Control	ICC/IF: HeLa cells, HAP1-WT and HAP1-IGF2R knockout cells.
Application	ICC/IF

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C. Store in the dark
Storage Buffer	pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: 30% Glycerol, 1% BSA, PBS
Handling	Avoid freeze-thaw cycles.