Cat. No.: IBDA-434151
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Online InquiryTarget Information
| Target Name | M6PR (cation independent) |
| Uniprot ID | P11717 |
| Cellular Localization | Lysosome membrane. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface. |
| Immunogen | Synthetic peptide. |
| Function | Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. |
Product Details
| Description | Rabbit monoclonal antibody to M6PR (cation independent) - Lysosome Membrane Marker. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Alexa Fluor® 488 |
| Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Positive Control | ICC/IF: HeLa cells, HAP1 WT and HAP1-IGF2R knockout cells |
| Application | ICC/IF |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C. Store in the dark |
| Storage Buffer | pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: 30% Glycerol, 1% BSA, PBS |
| Handling | Avoid freeze-thaw cycles. |