M6PR (cation independent) Monoclonal Antibody

Target Information

Target Name	M6PR (cation independent)
Uniprot ID	P11717
Cellular Localization	Lysosome membrane. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
Immunogen	Tissue, cells or virus corresponding to Vaccinia virus M6PR (cation independent).
Function	Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Product Details

Description	Mouse monoclonal antibody to M6PR (cation independent).
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Tissue, cells or virus corresponding to Vaccinia virus M6PR (cation independent).
Positive Control	Flow Cyt (Intra): HeLa cells.
Application	Flo

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.40 Preservative: 0.097% Sodium Azide Constituent: PBS
Handling	Avoid freeze-thaw cycles.