Cat. No.: IBDA-434166
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Online InquiryTarget Information
| Target Name | M6PR (cation independent) |
| Uniprot ID | P11717 |
| Cellular Localization | Lysosome membrane. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface. |
| Immunogen | Full length protein. |
| Function | Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. |
Product Details
| Description | Mouse monoclonal antibody to M6PR (cation independent). |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Purity | Protein G purified |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Full length protein. |
| Positive Control | Flow Cyt (Intra): A431 cells. ICC/IF: HAP1 cells (HAP1-IGF2R knockout cells used as negative cell line). |
| Application | Flo, ICC/IF |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: PBS, 6.97% L-Arginine |
| Handling | Avoid freeze-thaw cycles. |