MAdCAM1 Monoclonal Antibody

Target Information

Target Name	MAdCAM1
Uniprot ID	Q13477
Cellular Localization	Membrane.
Immunogen	Recombinant fragment.
Function	Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.

Product Details

Description	Rabbit monoclonal antibody to MAdCAM1.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant fragment.
Positive Control	WB: Human colon, small intestine and stomach tissue lysate. His-tagged human MAdCAM1 recombinant fragment. IHC-P: Human gastric carcinoma, colon and stomach tissue. HEK-293T transfected with a MADCAM1 expression vector containing a Myc-His tag. ICC/IF: HEK-293T cells transfected with a human MAdCAM1 expression vector containing a myc tag. Flow Cyt: HEK-293T cells transfected with a human MAdCAM1 expression vector containing a myc tag.
Application	Flo, ICC/IF, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 59% PBS, 40% Glycerol, 0.05% BSA
Handling	Avoid freeze-thaw cycles.