Manzamine A

Cat. No.: IBDI-430018

Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1.

Product Details

Target	GSK-3 | CDK | PaRasite | Proton Pump | HSV | Autophagy
Molecular Weight	548.76
Synonyms	Keramamine A
SMILES	O[[email protected]]1(CC/C=C\CCCC2)[[email protected]@]3([H])[[email protected]@](C[[email protected]@]4([H])N3CCCC/C=C\4)(C[[email protected]@]2CC5)[[email protected]]5([H])C(C6=C(NC7=CC=CC=C87)C8=CC=N6)=C1
Structure Classification	Alkaloids

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.