Maxi Potassium Channel Alpha/SLO Polyclonal Antibody

Target Information

Target Name	Maxi Potassium Channel Alpha/SLO
Uniprot ID	Q12791
Cellular Localization	Cell membrane.
Immunogen	Synthetic peptide corresponding to Human Maxi Potassium channel alpha/SLO (internal sequence).
Function	Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

Product Details

Description	Rabbit polyclonal antibody to Maxi Potassium channel alpha/SLO.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide corresponding to Human Maxi Potassium channel alpha/SLO (internal sequence).
Positive Control	Human breast, vessel tissue.
Application	IHC-P

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.4 Preservative: 0.099% Sodium Azide Constituent: 99% PBS
Handling	Avoid freeze-thaw cycles.