Cat. No.: IBDA-433964
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Online InquiryTarget Information
| Target Name | MIF |
| Uniprot ID | P14174 |
| Cellular Localization | Secreted. Cytoplasm. Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. |
| Immunogen | Synthetic peptide. |
| Function | Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. |
Product Details
| Description | HRP Rabbit monoclonal antibody to MIF. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | HRP |
| Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Positive Control | WB: Y70 whole cell lysate and Human Fetal Brain tissue lysate. |
| Application | WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C. Store in the dark |
| Storage Buffer | pH: 7.40 Preservative: 0.1% Proclin 300 Solution Constituent: 30% Glycerol, 1% BSA, PBS |
| Handling | Avoid freeze-thaw cycles. |