MIF Monoclonal Antibody

Target Information

Target Name	MIF
Uniprot ID	P14174
Cellular Localization	Secreted. Cytoplasm. Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
Immunogen	Recombinant full length protein, corresponding to amino acids 1-116 of Human MIF.
Function	Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

Product Details

Description	Mouse monoclonal antibody to MIF.
Host Species	Mouse
Clonality	Monoclonal
Purity	Tissue culture supernatant
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Human, Recombinant fragment
Immunogen	Recombinant full length protein, corresponding to amino acids 1-116 of Human MIF.
Positive Control	IHC-P: Human lung cell carcinoma tissue. Flow Cyt: Jurkat cells.
Application	Flo, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	pH: 7.4
Handling	Avoid freeze-thaw cycles.