Mouse IKB alpha Antibody Pair - BSA and Azide free

Overview

Assay Type	ELISA set
Product Type	TLR Signaling
Range	62.5 pg/ml - 4000 pg/ml
Species Reactivity	Reacts with: Mouse
Platform	Reagents
Application	Sandwich ELISA

Properties

Carrier Free

Yes

Target

Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Sequence Similarities	Belongs to the NF-kappa-B inhibitor family. Contains 5 ANK repeats.
Cellular Localization	Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.

Storage & Handling

Storage	Store at +4°C.
Storage Buffer	Constituent: 100% PBS