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MS143

Cat. No.: IBDI-435993

MS143 is a potent AKT degrader (DC50=46 nM and GI50=0.8 µM in PC3 cells). MS143 induces rapid and robust AKT degradation in a concentration- and time-dependent manner via hijacking the ubiquitin-proteasome system. MS143 can suppress cancer cell growth.

Size (Solid):

Product Details

Target Akt
Molecular Weight 1121.87
SMILES O=C(N1[[email protected]@H](C[[email protected]](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[[email protected]](C(C)(C)C)NC(CCCCCCCCCCC(N(CC4)CCN4CC[[email protected]@H](C5=CC=C(C=C5)Cl)NC(C6(CCN(CC6)C7=C8C(NC=C8)=NC=N7)N)=O)=O)=O

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.